4-(4-氰基-苄基)-哌啶-1-羧酸叔丁酯合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; methanol T=20°C;
参考文献
Imamura, Shinichi; Ichikawa, Takashi; Nishikawa, Youichi; Kanzaki, Naoyuki; Takashima, Katsunori; Niwa, Shinichi; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2784 - 2793
反应条件
in 1,4-dioxane; water T=20°C;
参考文献
RITCHER GEDEON NYRT
Patent: WO2008/50168 A1, 2008 ;
Location in patent: Page/Page column 31 ;
WO 2008/050168 A1
反应条件
1.1: 15-crown-5; NaH / tetrahydrofuran / 20 °C 1.2: tetrahydrofuran / 20 °C 2.1: 70 percent / H2 / Pd/C / methanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Imamura, Shinichi; Ichikawa, Takashi; Nishikawa, Youichi; Kanzaki, Naoyuki; Takashima, Katsunori; Niwa, Shinichi; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2784 - 2793
反应条件
1.1: 20 h / 150 °C 2.1: 15-crown-5; NaH / tetrahydrofuran / 20 °C 2.2: tetrahydrofuran / 20 °C 3.1: 70 percent / H2 / Pd/C / methanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Imamura, Shinichi; Ichikawa, Takashi; Nishikawa, Youichi; Kanzaki, Naoyuki; Takashima, Katsunori; Niwa, Shinichi; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2784 - 2793
