N-(3-((5-氯-1H-吡咯并[2,3-b]吡啶-3-基)(羟基)甲基)-2,4-二氟苯基)-1-丙磺酰胺合成路线 （共 3 条）
反应条件
potassium carbonate in methanol; water T=130°C; 0.5 h; Microwave irradiation;
参考文献
Uddin, Md. Imam; Buck, Jason R.; Schulte, Michael L.; Tang, Dewei; Saleh, Samir A.; Cheung, Yiu-Yin; Harp, Joel; Manning, H. Charles
Tetrahedron Letters, 2014 , vol. 55, # 1 p. 169 - 173
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere 1.2: 1.5 h / -78 - 110 °C / Microwave irradiation 2.1: potassium carbonate / methanol; water / 0.5 h / 130 °C / Microwave irradiation View Scheme
参考文献
Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4161 - 4165
反应条件
1.1: pyridine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0.5 h / 100 °C / Microwave irradiation 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere 2.2: 1.5 h / -78 - 110 °C / Microwave irradiation 3.1: potassium carbonate / methanol; water / 0.5 h / 130 °C / Microwave irradiation View Scheme
参考文献
Buck, Jason R.; Saleh, Sam; Imam Uddin, Md.; Manning, H. Charles
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4161 - 4165
