叔丁基二甲基硅氧烷基乙醛合成路线 （共 20 条）
反应条件
diisobutylaluminium hydride in diethyl ether; hexane T=-78°C;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 14 p. 2817 - 2828
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=0°C; 2 h; Inert atmosphere; 2: With methanol in tetrahydrofuran; hexane T=0 - 20°C; Inert atmosphere;
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 28, # 8 p. 761 - 771
反应条件
1: 2N HCl / tetrahydrofuran / 3 h / Ambient temperature 2: sodium metaperiodate / CH2Cl2; H2O View Scheme
参考文献
Synthetic Communications, , vol. 18, # 4 p. 359 - 366
参考文献
Angewandte Chemie, , vol. 106, # 22 p. 2416 - 2418
反应条件
1: 58 percent 2: 69 percent / t-BuOOLi 3: 28 percent / MgBr2*OEt2, tetra-n-butylammonium borohydride / diethyl ether; CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Bailey, Peter L.; Briggs, Andrew D.; Jackson, Richard F. W.; Pietruszka, Joerg
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 20 p. 3359 - 3363
反应条件
hydrogenchloride; water in tetrahydrofuran T=0 - 4°C; 18 h; Product distribution / selectivity;
参考文献
WO2008/34598 A1, ;
Page/Page column 24-25 ;
反应条件
potassium carbonate in water
参考文献
Parsons, Philip J.; Lacrouts, Pierre; Buss, A. D.
Journal of the Chemical Society, Chemical Communications, 1995 , # 4 p. 437 - 438
反应条件
in tetrahydrofuran; dichloromethane
1) -78 deg C, 1 h, 2) -78 deg C to r.t., 1 h; Yield given;
参考文献
Jones; Storey
Tetrahedron, 1993 , vol. 49, # 22 p. 4901 - 4906
反应条件
copper sulfate in dichloromethane
T=20°C; 48 h;
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven W.; CONDROSKI, Kevin Ronald; DE MEESE, Lisa A.; FELL, Jay Bradford; FISCHER, John P.; LE HUEROU, Yvan; JOSEY, John A.; KOCH, Kevin; MIKNIS, Gregory F.; RODRIGUEZ, Martha E.; TOPALOV, George T.; WALLACE, Eli M.; XU, Rui
Patent: WO2011/29027 A1, 2011 ;
Location in patent: Page/Page column 121 ;
WO 2011/029027 A1
