6-溴-1,2-二氢-2-氧代-3H-咪唑并[4,5-b]吡啶-3-羧酸,1,1-二甲基乙酯合成路线 （共 3 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 1.5 h; 2: With isopropylamine in tetrahydrofuran 0.5 h;
参考文献
SIGNAL PHARMACEUTICALS, LLC
Patent: WO2008/51493 A2, 2008 ;
Location in patent: Page/Page column 210 ;
反应条件
1: tetrahydrofuran / 60 °C 2: potassium carbonate / acetonitrile 3: 4-(N,N-dimethlyamino)pyridine View Scheme
参考文献
UNIVERSITY OF ROCHESTER; BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA; GELBARD, Harris A.; DEWHURST, Stephen; GENDELMAN, Howard E.
Patent: WO2014/85795 A1, 2014 ;
反应条件
1: potassium carbonate / acetonitrile 2: 4-(N,N-dimethlyamino)pyridine View Scheme
参考文献
UNIVERSITY OF ROCHESTER; GELBARD, Harris, A.; DEWHURST, Stephen; GOODFELLOW, Val, S.; WIEMANN, Torsten; RAVULA, Satheesh, Babu; LOWETH, Colin, J.
Patent: WO2011/149950 A2, 2011 ;
WO 2011/149950 A2
