Boc-4-氧代-L-脯氨酸甲酯合成路线 （共 35 条）
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 0°C; Oxidation;
参考文献
O'Connell, Celeste E.; Rowell, Cheryl A.; Ackermann, Karen; Garcia, Ana Maria; Lewis, Michael D.; Kowalczyk, James J.
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 5 p. 740 - 742
反应条件
triethylamine in dichloromethane
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US6531474 B1, 2003 ;
US 6531474 B1
反应条件
tetrapropylammonium perruthennate in dichloromethane T=20°C;
参考文献
WO2008/51404 A2, ;
Page/Page column 106 ;
WO 2008/051404 A2
反应条件
1: 95 percent / aq. NaOH / dioxane / 7 h / 20 °C 2: 88 percent / Cs2CO3 / methanol; dimethylformamide / 20 h / 20 °C 3: 81 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 15 p. 4121 - 4143
反应条件
1: 99 percent / Et3N / CH2Cl2 / 4 h / 0 °C 2: 91 percent / (COCl)2; Et3N; DMSO / CH2Cl2 / -40 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 2 p. 499 - 504
反应条件
1: 95 percent / aq. NaOH / dioxane / 7 h / 20 °C 2: 88 percent / Cs2CO3 / methanol; dimethylformamide / 20 h / 20 °C 3: 81 percent / Dess-Martin periodinane / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 15 p. 4121 - 4143
反应条件
1: 17.7 g / triethylamine / dimethylformamide / 1.5 h / 55 °C 2: 90 percent / N-methylmorpholine-N-oxide; 4 Angstroem molecular sieves; tetrapropylammonium perruthenate / CH2Cl2 / 3.5 h / 35 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 30 p. 4985 - 4987
反应条件
in methanol; toluene
反应条件
in methanol; toluene
反应条件
in methanol; n-heptane; dichloromethane T=0 - 20°C; 18 h; Inert atmosphere;
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 12 p. 1024 - 1028
