2-苯基-4-氨基喹唑啉合成路线 （共 23 条）
反应条件
1: 86 percent / pyridine / 3 h / Heating
2: 69 percent / NH2OH / methanol / 4 h / 95 °C
3: 78 percent / conc. HCl, H2 / 8percent Pd/C / dioxane
View Scheme
参考文献
Korbonits, Dezsoe; Kanzel-Szvoboda, Ida; Goenczi, Csaba; Simon, Kalman; Kolonits, Pal
Chemische Berichte, 1989 , vol. 122, p. 1107 - 1112
反应条件
1: 70 percent / Et3N / acetone / 2 h / 5 °C
2: conc. HCl / ethanol / 2 h / Heating
3: 78 percent / conc. HCl, H2 / 8percent Pd/C / dioxane
View Scheme
参考文献
Korbonits, Dezsoe; Kanzel-Szvoboda, Ida; Goenczi, Csaba; Simon, Kalman; Kolonits, Pal
Chemische Berichte, 1989 , vol. 122, p. 1107 - 1112
反应条件
C8H17SH in 1,3,5-trimethyl-benzene
T=150°C; 16 h;
参考文献
Wentrup, Curt; Thetaz, Celestin; Tagliaferri, Enrico; Lindner, Hans Joerg; Kitschke, Brigitte; et al.
Angewandte Chemie, 1980 , vol. 92, # 7 p. 556 - 557
反应条件
in N,N-dimethyl-formamide
T=80°C; 6 h;
参考文献
Fathalla, Walid; Cajan, Michal; Marek, Jaromir; Pazdera, Pavel
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1145 - 1152
反应条件
1: 85 percent / NaOH / aq. ethanol / 2 h / Heating
2: 90 percent / conc. HCl, H2 / 8percent Pd/C / dioxane
View Scheme
参考文献
Korbonits, Dezsoe; Kanzel-Szvoboda, Ida; Goenczi, Csaba; Simon, Kalman; Kolonits, Pal
Chemische Berichte, 1989 , vol. 122, p. 1107 - 1112
反应条件
1.1: PCl5 / benzene / 50 °C
2.1: benzene; diethyl ether / 20 °C
3.1: TiCl4 / benzene; diethyl ether / 3 h / 50 °C
3.2: aq. NaOH
View Scheme
参考文献
Zielinski, Wojciech; Kudelko, Agnieszka
Monatshefte fur Chemie, 2000 , vol. 131, # 8 p. 895 - 899
反应条件
1.1: benzene; diethyl ether / 20 °C
2.1: TiCl4 / benzene; diethyl ether / 3 h / 50 °C
2.2: aq. NaOH
View Scheme
参考文献
Zielinski, Wojciech; Kudelko, Agnieszka
Monatshefte fur Chemie, 2000 , vol. 131, # 8 p. 895 - 899
反应条件
1: triethylamine / benzene
2: 1.) P2O5, N,N-dimethylcyclohexylamine, ammonium chloride, 2.) water / 1.) 180 deg C, 40 min, 2.) 100 deg C, 90 min
View Scheme
参考文献
Nielsen, Knud Erik; Pedersen, Erik B.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1980 , vol. 34, # 9 p. 637 - 642
反应条件
1.1: trichlorophosphate / 2 h / Reflux
2.1: phenol / 2 h / 170 °C
2.2: 1 h / 150 °C
View Scheme
参考文献
Marvania, Bhavin; Lee, Pei-Chih; Chaniyara, Ravi; Dong, Huajin; Suman, Sharda; Kakadiya, Rajesh; Chou, Ting-Chao; Lee, Te-Chang; Shah, Anamik; Su, Tsann-Long
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 1987 - 1998
反应条件
1: 40 percent / dimethylformamide / 80 °C
2: dimethylformamide / 6 h / 80 °C
View Scheme
参考文献
Fathalla, Walid; Cajan, Michal; Marek, Jaromir; Pazdera, Pavel
Journal of Heterocyclic Chemistry, 2002 , vol. 39, # 6 p. 1145 - 1152
