1H-吲哚-2-基(苯基)甲酮合成路线 （共 61 条）
反应条件
potassium carbonate; lithium chloride; palladium diacetate in N,N-dimethyl-formamide
T=100°C; Cyclization; 16 h;
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
反应条件
potassium carbonate in PEG-400
T=100°C; 3 h; Inert atmosphere;
参考文献
Zhao, Yu; Li, Deyao; Zhao, Liwen; Zhang, Jiancun
Synthesis, 2011 , # 6 art. no. F20910SS, p. 873 - 880
反应条件
1: 2-(dimethyl-λ4-sulfanylidene)-1-phenyl-ethanone With caesium carbonate in anhydrous xylene
T=20°C; 0.5 h;
2: N-(2-(chloromethyl)phenyl)-4-methylbenzenesulfonamide in anhydrous xylene
T=20°C;
参考文献
Yang, Qing-Qing; Xiao, Cong; Lu, Liang-Qiu; An, Jing; Tan, Fen; Li, Bin-Jie; Xiao, Wen-Jing
Angewandte Chemie - International Edition, 2012 , vol. 51, # 36 p. 9137 - 9140
参考文献
THE UNIVERSITY OF BRITISH COLUMBIA; SIMON FRASER UNIVERSITY; REINER, Neil E.; FINLAY, Barton B.; BRUNHAM, Robert C.; TCHERKASSOV, Artem; FOSTER, Leonard J.; MCMASTER, William R.; SEE, Raymond H.; ZORAGHI, Roya; HSING, Michael M. K.; BYLER, Kendall G.; AXERIO-CILIES, Peter J.; BAN, Fuqiang; KUMAR, Nag; MOREAU, Anne; LABRIERE, Christophe; YOUNG, Robert N.
Patent: WO2012/51708 A1, 2012 ;
Location in patent: Page/Page column 49 ;
WO 2012/051708 A1
反应条件
sodium hydroxide in N,N-dimethyl-formamide
参考文献
Gorgos, V. I.; Zorin, L. M.; Zhungietu, G. I.; Rekhter, M. A.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983 , vol. 19, # 11 p. 1179 - 1181
Khimiya Geterotsiklicheskikh Soedinenii, 1983 , # 11 p. 1490 - 1492
反应条件
1: indole-2,3-dione With sodium hydroxide in methanol
1 h; Reflux;
2: α-bromoacetophenone in N,N-dimethyl-formamide
T=100°C; 16 h;
参考文献
Santoso, Mardi; Kumar, Naresh; Black, David Stclair
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 7-8 p. 1137 - 1150
反应条件
1: tert-butyl N-indolecarboxylate With n-butyllithium; CuCl2*TMEDA; 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran; hexanes
T=20°C; 2 h; Inert atmosphere;
2: benzoyl chloride in tetrahydrofuran; hexanes
T=0 - 60°C; 16 h; Inert atmosphere;
3: With trifluoroacetic acid in dichloromethane
T=20°C;
参考文献
Nguyen, Tan Tai; Marquise, Nada; Chevallier, Floris; Mongin, Florence
Chemistry - A European Journal, 2011 , vol. 17, # 37 p. 10405 - 10416
反应条件
ethanol; potassium hydroxide
T=20°C; 1 h;
参考文献
Zhou, Bing; Yang, Yaxi; Li, Yuanchao
Chemical Communications, 2012 , vol. 48, # 42 p. 5163 - 5165
反应条件
potassium hydroxide in methanol
5 h; Heating;
参考文献
Miki, Yasuyoshi
Heterocycles, 1997 , vol. 45, # 6 p. 1143 - 1150
反应条件
indium; ammonium chloride in methanol
4.5 h; Heating;
参考文献
Han, Rongbi; Chen, Shen; Lee, Sun Jung; Qi, Fang; Wu, Xue; Kim, Byeong Hyo
Heterocycles, 2006 , vol. 68, # 8 p. 1675 - 1684
