2-(2,3-二氟-6-硝基苯基)-3-氧代丁酸叔丁酯合成路线 (共 1 条)
反应条件
1: acetoacetic acid tert-butyl ester With sodium tert-pentoxide in toluene T=40°C; 2: 1,2,3-trifluoro-4-nitrobenzene in toluene T=70°C; 3 h; 3: With sulfuric acid in water; toluene T=25°C; pH=1; Product distribution / selectivity;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/53221 A2, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/053221 A2