6-羟基-1,3-二甲基-7-亚硝基-9-(苯基甲基)-嘧啶并[2,1-f]嘌呤-2,4,8(1H,3H,9H)-三酮合成路线 （共 3 条）
反应条件
acetic acid; sodium nitrite in water 1.) 0 deg C, 5 min, 2.) RT, 75 min;
参考文献
Blythin; Kaminski; Domalski; Spitler; Solomon; Conn; Wong; Verbiar; Bober; Chiu
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1099 - 1113
反应条件
1: NaOMe / 9 h / 200 - 210 °C 2: 81 percent / AcOH, sodium nitrite / H2O / 1.) 0 deg C, 5 min, 2.) RT, 75 min View Scheme
参考文献
Blythin; Kaminski; Domalski; Spitler; Solomon; Conn; Wong; Verbiar; Bober; Chiu
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1099 - 1113
反应条件
1: 87 percent / 4 h / Heating 2: NaOMe / 9 h / 200 - 210 °C 3: 81 percent / AcOH, sodium nitrite / H2O / 1.) 0 deg C, 5 min, 2.) RT, 75 min View Scheme
参考文献
Blythin; Kaminski; Domalski; Spitler; Solomon; Conn; Wong; Verbiar; Bober; Chiu
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1099 - 1113
