3-溴喹啉-6-基 乙酸酯合成路线 （共 5 条）
反应条件
pyridine; bromine in tetrachloromethane 2 h; Heating / reflux;
参考文献
SGX PHARMACEUTICALS, INC.
Patent: WO2008/144767 A1, 2008 ;
Location in patent: Page/Page column 119-120 ;
WO 2008/144767 A1
反应条件
1: pyridine / dichloromethane / 8 h / 0 - 20 °C 2: bromine; pyridine / tetrachloromethane / 3 h / 0 - 90 °C View Scheme
参考文献
WO2012/107500 A1, ;
WO 2012/107500 A1
反应条件
1: potassium carbonate; methanol / water / 2 h / 20 °C 2: potassium carbonate / acetone / 20 °C View Scheme
参考文献
NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue
Patent: US2013/245002 A1, 2013 ;
反应条件
methanol; potassium carbonate in water T=20°C; 2 h;
参考文献
NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue
Patent: US2013/245002 A1, 2013 ;
Location in patent: Paragraph 0702 ;
反应条件
1: potassium carbonate; water / methanol / 2 h / 20 °C
2: potassium carbonate / acetone / 20 °C
3: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium(0); 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene / toluene / 8.16 h / 100 °C / |Inert atmosphere
4: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 60 °C / 760.05 Torr
View Scheme
参考文献
NOVARTIS AG; CHEN, Chao; DENG, Haibing; GUO, Haibing; HE, Feng; JIANG, Lei; LIANG, Fang; MI, Yuan; WAN, Huixin; XU, Yao-Chang; YU, Hongping; ZHANG, Ji Yue
Patent: US2013/245002 A1, 2013 ;
