4-(叔丁基二甲基甲硅烷氧基)-2-丁酸合成路线 （共 3 条）
反应条件
1: dimethyl(1,1-dimethylethyl)(2-propynyloxy)silane With methylmagnesium bromide in tetrahydrofuran; diethyl ether T=0 - 20°C; 4 h; 2: carbon dioxide in tetrahydrofuran; diethyl ether Further stages.;
参考文献
Tsou; Mamuya; Johnson; Reich; Gruber; Ye; Nilakantan; Shen; Discafani; DeBlanc; Davis; Koehn; Greenberger; Wang; Wissner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2719 - 2734
反应条件
1.1: 64 percent / Et3N; 4-(dimethylamino)pyridine / CH2Cl2 / 21 h / 20 °C 2.1: MeMgBr / tetrahydrofuran; diethyl ether / 4 h / 0 - 20 °C 2.2: 6.28 g / tetrahydrofuran; diethyl ether View Scheme
参考文献
Tsou; Mamuya; Johnson; Reich; Gruber; Ye; Nilakantan; Shen; Discafani; DeBlanc; Davis; Koehn; Greenberger; Wang; Wissner
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2719 - 2734
反应条件
in N,N-dimethyl-formamide
参考文献
The Du Pont Merck Pharmaceutical Company
Patent: US5395844 A1, 1995 ;
