4-苯基-3-丁炔-1-醇合成路线 （共 39 条）
反应条件
1: phenylacetylene With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 1 h;
2: oxirane With trimethylaluminum in tetrahydrofuran; hexane
T=20°C; 24 h;
参考文献
Brummond, Kay M.; McCabe, Jamie M.
Synlett, 2005 , # 16 art. no. S06305ST, p. 2457 - 2460
反应条件
piperidine; tetrakis(triphenylphosphine) palladium(0)
T=80°C; 1 h;
参考文献
Alami; Ferri; Linstrumelle
Tetrahedron Letters, 1993 , vol. 34, # 40 p. 6403 - 6406
反应条件
TMG in tetrahydrofuran; hexane
2 h; Ambient temperaturewithout cat.;
参考文献
Fukuda, Yukitoshi; Matsubara, Seijiro; Lambert, Claude; Shiragami, Hiroshi; Nanko, Toshiki; et al.
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 6 p. 1810 - 1813
反应条件
1: 1,1-dibromostyrene With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; Corey-Fuchs reaction; Inert atmosphere;
2: With trimethylaluminum in tetrahydrofuran; hexane
T=0°C; Corey-Fuchs reaction; Inert atmosphere;
3: oxirane in tetrahydrofuran; hexane
T=-78 - 20°C; Corey-Fuchs reaction; Inert atmosphere;
参考文献
Smith, Sean M.; Takacs, James M.
Organic Letters, 2010 , vol. 12, # 20 p. 4612 - 4615
反应条件
sodium carbonate in various solvent(s)
T=80°C; 288 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
sodium carbonate in ethanol; water
T=25°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
triethylamine in ethanol; water
T=25°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
sodium carbonate in water
T=25°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride
T=50°C;
参考文献
Kang, Song Su; Yum, Eul Kgun; Sung, Nack-Do
Heterocycles, 2003 , vol. 60, # 12 p. 2727 - 2736
反应条件
ethanol; triethylamine
参考文献
Hanack,M. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 100 - 108
