2-溴-1-(2,2-二甲基-4H-1,3-苯并二噁英-6-基)乙酮合成路线 （共 9 条）
反应条件
1: With sodium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1 h; 2: With chloro-trimethyl-silane in tetrahydrofuran T=-78°C; 0.5 h; 3: With bromine in tetrahydrofuran T=-78°C; 1 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/9950 A1, 2010 ;
Location in patent: Page/Page column 21 ;
US 20100009950 A1
反应条件
toluene-4-sulfonic acid in dichloromethane T=0°C; 0.666667 h;
参考文献
Procopiou, Panayiotis A.; Morton, Gillian E.; Todd, Martin; Webb, Graham
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2005 - 2008
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Liu, Juntao; Zhou, Di; Jia, Xian; Huang, Ling; Li, Xingshu; Chan, Albert S.C.
Tetrahedron Asymmetry, 2008 , vol. 19, # 15 p. 1824 - 1828
反应条件
1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 2: 1N HBr / tetrahydrofuran / 75 °C 3: resin-SO3H / CH2Cl2 View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1: 1N HBr / tetrahydrofuran / 75 °C 2: resin-SO3H / CH2Cl2 View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1.1: resin-bound piperazinomethylpolystyrene / H2O; tetrahydrofuran 1.2: 14 percent / pTSA / toluene / 110 °C 2.1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 3.1: 1N HBr / tetrahydrofuran / 75 °C 4.1: resin-SO3H / CH2Cl2 View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 15 h / |Reflux 2: sodium tetrahydroborate; acetic acid / 1 h / 10 °C 3: dichloromethane / 10 h / 20 °C View Scheme
参考文献
Liu, Anqiu; Huang, Ling; Wang, Zhiren; Luo, Zonghua; Mao, Fei; Shan, Wenjun; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1548 - 1552
反应条件
1: sodium tetrahydroborate; acetic acid / 1 h / 10 °C 2: dichloromethane / 10 h / 20 °C View Scheme
参考文献
Liu, Anqiu; Huang, Ling; Wang, Zhiren; Luo, Zonghua; Mao, Fei; Shan, Wenjun; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1548 - 1552
反应条件
1: 28 percent / Cs2CO3 / acetonitrile / 24 h / 21 °C 2: 43 percent / CF3CO2H / CH2Cl2 / 4 h / 20 °C 3: 99 percent / (R)-tetrahydro-1-Me-3,3-Ph2-1H,3H-pyrrolo[1,2-c][1,3-2]oxaza; borole; BH3*THF / toluene / 5 - 20 °C 4: 70 percent / NaH / dimethylformamide / 3 h / 20 °C View Scheme
参考文献
Coe, Diane M; Perciaccante, Rossana; Procopiou, Panayiotis A
Organic and biomolecular chemistry, 2003 , vol. 1, # 7 p. 1106 - 1111
