N-Boc-3-氨甲基吡啶合成路线 （共 10 条）
反应条件
in 1,4-dioxane 3 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
C45H59ClNPPd; potassium carbonate in water; tert-butyl alcohol T=85°C; Suzuki-Miyaura Coupling; 3 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 15, # 10 p. 2534 - 2537
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; dichloro(cycloocta-1,5-diene)palladium(II) in water; tert-butyl alcohol T=95°C; Suzuki-Miyaura cross-coupling; 22 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 14, # 12 p. 3138 - 3141
反应条件
[Mo(CO)3(acetonitrile)3] in methanol T=130°C; SonicationMicrowave irradiationInert atmosphere; chemoselective reaction;
参考文献
Chemistry - A European Journal, , vol. 16, # 15 p. 4557 - 4566
反应条件
in 1,4-dioxane; water Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2222 - 2227
反应条件
1: 1.) sodium hydride / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 2 h 2: HCl / dioxane / 0.5 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330
反应条件
2: 56 percent / s-BuLi, TMEDA / tetrahydrofuran View Scheme
参考文献
Beak; Wu; Eul Kyun Yum; Young Moo Jun
Journal of Organic Chemistry, 1994 , vol. 59, # 2 p. 276 - 277
反应条件
hydrogen; ruthenium in methanol T=60°C; P=75006 Torr;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901
反应条件
1.1: hydrogen / Rh/Al2O3 / methanol / 16 h / 50 °C / 30003 Torr
2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 16 h
2.2: pH ~ 14
3.1: trifluoroacetic acid / dichloromethane / 18 h / 0 °C
3.2: pH ~ 14
View Scheme
参考文献
PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles
Patent: WO2011/117254 A1, 2011 ;
WO 2011/117254 A1
反应条件
1: With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - -20°C;
2: With boric acid trimethyl ester in tetrahydrofuran; pentane
T=-20 - 20°C;
3: With hydrogenchloride in tetrahydrofuran; pentane
Further stages.;
参考文献
Peukert, Stefan; Brendel, Joachim; Pirard, Bernard; Brueggemann, Andrea; Below, Peter; Kleemann, Heinz-Werner; Hemmerle, Horst; Schmidt, Wolfgang
Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 486 - 498
