1: With (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; meta-nitrobenzoic acid in toluene T=3°C; Michael addition; Cooling with ice; 2: With sodium tetrahydroborate in methanol; toluene T=0°C; 3: With ammonium chloride in methanol; toluene T=0°C;

1: With 4-methyl-morpholine in chloroform T=20°C; 20 h; 2: With borane in tetrahydrofuran; chloroform T=-15°C; 1 h; Further stages. Title compound not separated from byproducts.;

1: With sodium tetrahydroborate in ethanol; hexane; water 0.5 h; 2: With hydrogenchloride in ethanol; hexane; water pH=3; Product distribution / selectivity;