4-甲氧基-2-苯基苯乙酮合成路线 （共 128 条）
反应条件
1: potassium tert-butylate / diethyl ether / Heating
2: tetrahydrofuran / Heating
3: 47percent HBr / tetrahydrofuran
View Scheme
参考文献
Schneider, Martin R.; Angerer, Erwin von; Schoenenberger, Helmut; Michel, Ralf Th.; Fortmeyer, H. P.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1070 - 1077
反应条件
1: methanol. KOH
2: zinc-powder; acetic acid
3: aqueous H2SO4; acetic acid
4: N,N-dimethyl-4-nitroso-aniline; sodium methylate; benzene and methanol / anschliessend mit wss. HCl
View Scheme
参考文献
Mehr et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 984,987
反应条件
1: 97 percent / Zn; I2 / benzene / 1 h / Heating
2: 90 percent / Et3SiH; TFA; BF3*Et2O / CH2Cl2 / 8 h / Heating
3: 92 percent / aq. KOH / 8 h / Heating
4: 85 percent / polyphosphoric acid / 1 h / 80 °C
5: 93 percent / HBr; AcOH / 6 h / Heating
View Scheme
参考文献
Jung, Jae-Chul; Lee, Ji-Ho; Oh, Seikwan; Lee, Jae-Gon; Park, Oee-Sook
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5527 - 5531
反应条件
1: bromine / CHCl3
2: ethanol / Heating
View Scheme
参考文献
Liu; He; Li; Zhong
Current Medicinal Chemistry, 2012 , vol. 19, # 35 p. 6072 - 6079
反应条件
1: potassium tert-butylate / diethyl ether / Heating
2: tetrahydrofuran / Heating
3: 47percent HBr / tetrahydrofuran
4: 62.4 percent / BBr3 / CH2Cl2 / 72 h / 20 °C
View Scheme
参考文献
Schneider, Martin R.; Angerer, Erwin von; Schoenenberger, Helmut; Michel, Ralf Th.; Fortmeyer, H. P.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1070 - 1077
反应条件
piperidine; acetic acid in benzene
28 h; Heating;
参考文献
Verma, Braham S.; Dhindsa, Kuldip Singh; Sangwan, Naresh K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 2 p. 239 - 243
反应条件
piperidine; acetic acid in benzene
24 h; Heating;
参考文献
Kumar, Surat; Rastogi, Shri Nivas
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 968 - 971
反应条件
N-bromosuccinmide; dimethyl sulfoxide
72 h; Ambient temperature;
参考文献
Tatsugi, Jiro; Izawa, Yasuji
Journal of Chemical Research, Miniprint, 1988 , # 11 p. 2747 - 2763
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: With 2-benzenesulfonyl-3-phenyl-oxaziridine in tetrahydrofuran
T=-78°C;
参考文献
Sklute, Genia; Oizerowich, Rachel; Shulman, Hagit; Keinan, Ehud
Chemistry - A European Journal, 2004 , vol. 10, # 9 p. 2159 - 2165
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 1098244/; Multistep reaction;
参考文献
Arnold,D.R. et al.
Journal of the American Chemical Society, 1976 , vol. 98, # 20 p. 6225 - 6233
