4-甲氧基-2-苯基苯乙酮合成路线 （共 128 条）
反应条件
1: (diethylamino)(4-methoxyphenyl)acetonitrile With sodium hydride in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: benzyl chloride in DMF (N,N-dimethyl-formamide) T=20°C; 3: With hydrogenchloride; methanol; water more than 3 stages;
参考文献
WO2004/11410 A1, ;
Page 78-79 ;
WO 2004/011410 A1
反应条件
hydrogenchloride in tetrahydrofuran; water T=25°C;
参考文献
Battace, Ahmed; Zair, Touriya; Doucet, Henri; Santelli, Maurice
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 459 - 462
反应条件
potassium phosphate; palladium diacetate; tri-cyclo-hexyl-phosphine in water T=80°C; Suzuki carbonylation; P=7500.75 Torr; 20 h; Inert atmosphere;
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
Tetrahedron Letters, 2010 , vol. 51, # 47 p. 6146 - 6149
反应条件
trans-[1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene]PdCl2(NC5H5); sodium t-butanolate in tetrahydrofuran T=70°C; 9 h; Inert atmosphere;
参考文献
Cao, Changsheng; Wang, Lingling; Cai, Zhengyuan; Zhang, Lingqiao; Guo, Jin; Pang, Guangsheng; Shi, Yanhui
European Journal of Organic Chemistry, 2011 , # 8 p. 1570 - 1574
反应条件
1,4-diaza-bicyclo[2.2.2]octane; water; oxygen in acetonitrile T=80°C; P=760.051 Torr; 12 h; chemoselective reaction;
参考文献
Su, Yijin; Sun, Xiang; Wu, Guolin; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9808 - 9812
Angew. Chem., 2013 , p. 9990 - 9994
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile T=50 - 55°C; 0.166667 h;
参考文献
Shankaran, R.; Talekar, D. G.; Rao, A. S.
Synthetic Communications, 1982 , vol. 12, # 2 p. 141 - 150
反应条件
1: 85 percent / acetic acid 2: sodium tert-butoxide / Pd2(dba)3; bis(2-diphenylphosphinophenyl)ether / dioxane / 24 h / 80 °C 3: 103 mg / aq. HCl / tetrahydrofuran; methanol / 16 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 128, # 46 p. 14800 - 14801
反应条件
methanesulfonic acid; sodium hydrogencarbonate in hexane; methoxybenzene
反应条件
1: 4-methoxy-α-methylbenzyl alcohol With [Pd(η3-allyl)(Cl)((N,N′-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene))]; 4-methyl-chlorobenzene; potassium tert-butylate in toluene T=40°C; 3 h; Inert atmosphere; 2: chlorobenzene in toluene T=80°C; 4 h; Inert atmosphere;
参考文献
Landers, Brant; Berini, Christophe; Wang, Chao; Navarro, Oscar
Journal of Organic Chemistry, 2011 , vol. 76, # 5 p. 1390 - 1397
反应条件
aluminium dodecatungstophosphate; trifluoroacetic anhydride T=20°C; 2 h;
参考文献
Firouzabadi, Habib; Iranpoor, Nasser; Nowrouzi, Farhad
Tetrahedron, 2004 , vol. 60, # 48 p. 10843 - 10850
