1,1-二苯基-1,4-丁二醇合成路线 （共 19 条）
反应条件
1: hydrogenchloride / ethanol; water / Reflux 2: carbon tetrabromide; triphenylphosphine / dichloromethane / 0 - 20 °C 3: hydrogen / palladium on activated charcoal / ethanol / 20 °C View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY; YUAN, Junying; YUAN, Chengye; CHEN, Gang; XIA, Hong-guang
Patent: WO2011/143444 A2, 2011 ;
反应条件
in tetrahydrofuran; 2-methyl tetrahydrofuran
T=0°C; Inert atmosphere;
参考文献
Huy, Peter H.; Westphal, Julia C.; Koskinen, Ari M.P.
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 369 - 383
反应条件
hydrogenchloride; ammonium chloride in tetrahydrofuran
参考文献
Ajinomoto Co., Inc.
Patent: EP1191021 A1, 2002 ;
Location in patent: Page 19-20 ;
EP 1191021 A1
反应条件
1: 3-iodo-prop-2 (Z)-ene-ol With isopropylmagnesium chloride in tetrahydrofuran
T=-78°C; 0.0833333 h;
2: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
3: benzophenone in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Further stages.;
参考文献
Fleming, Fraser F.; Gudipati, Subrahmanyam; Vu, Viet Anh; Mycka, Robert J.; Knochel, Paul
Organic Letters, 2007 , vol. 9, # 22 p. 4507 - 4509
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Warner-Lambert Company
Patent: US5767129 A1, 1998 ;
US 5767129 A
反应条件
1: bromobenzene With tert.-butyl lithium in diethyl ether; hexane
T=-78 - 20°C; Inert atmosphere;
2: tetrahydrofuran-2-one in diethyl ether; hexane
T=-78 - 20°C; Inert atmosphere; regioselective reaction;
参考文献
Miao, Lei; Dimaggio, Stassi C.; Trudell, Mark L.
Synthesis, 2010 , # 1 p. 91 - 97
参考文献
Weizmann; Bergmann
Journal of the American Chemical Society, 1938 , vol. 60, p. 2647,2649
反应条件
in diethyl ether
2 h; Heating;
参考文献
Lehmann, Jochen; Marquardt, Norbert
Synthesis, 1987 , # 12 p. 1064 - 1067
反应条件
1: KOH; THF
2: Raney nickel; ethanol / Hydrogenation
View Scheme
参考文献
Robert et al.
Bulletin de la Societe Chimique de France, 1956 , p. 1575,1578
反应条件
(i) EtMgBr, THF, (ii) Mg, (iii) /BRN= 1238185/; Multistep reaction;
参考文献
Umio; Ueda; Nojima
Journal of medicinal chemistry, 1972 , vol. 15, # 8 p. 855 - 856
