T=95°C; 840 h;

1: 91 percent / H2SO4 / 24 h / 20 °C 2: 93 percent / NaOMe / benzene; tetrahydrofuran; methanol / 8 h / Heating 3: 69 percent / KOH / ethanol / 24 h / Heating 4: 54 percent / PCl5 / chlorobenzene / 3 h / 20 °C 5: 89 percent / Zn; AcOH / 3 h 6: 55 percent / 48 h / 120 °C / in sealed tube View Scheme

1: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 0 - 20 °C 2: acetic anhydride / 12 h / 140 °C / |Inert atmosphere View Scheme

暂无反应条件数据

N-bromosuccinmide; triethylamine in dichloromethane T=20°C; Hunsdiecker reaction; 0.0833333 h;

Multi-step reaction with 8 steps 1.1: 86 percent / DMAP; DCC / CH2Cl2 / 0.33 h / 20 °C2.1: 61 percent / CsF; P(o-tol)3 / Pd2(dba)3*CHCl3 / acetonitrile / 4 h / 20 °C3.1: 78 percent / NaH / CH2Cl2 / 5 h / 20 °C4.1: DIBAL-H / CH2Cl2; toluene / 2 h / -78 °C4.2: 63 percent / aq. potassium sodium tartrate / CH2Cl2; methanol / -78 - 20 °C5.1: 95 percent / NaBH4 / methanol; tetrahydrofuran / 21 h / 20 °C6.1: 89 percent / molecular sieves 4 Angstroem; PCC / CH2Cl2 / 1.5 h / 0 °C7.1: mCPBA / CH2Cl2 / 1 h / 20 °C8.1: 54 mg / K2CO3 / methanol / 0.5 h / 20 °C