O,O-双(2-羟基乙氧基)苯合成路线 （共 18 条）
反应条件
1: 50 percent / 65percent nitric acid / CHCl3 / 0.5 h / 20 - 24 °C 2: 75 percent / 60percent aq. KOH / dicyclohexyl-18-crown-6 / tetrahydrofuran / 5 h / Heating 3: 71 percent / hydrazine hydrate / Pd/C / ethanol / 0.75 h / Heating View Scheme
参考文献
Abakumova, N. I.; Kolenko, I. K.; Kodess, M. I.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1305 - 1307
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 7 p. 1495 - 1498
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in toluene 16 h; Heating;
参考文献
Bogaschenko, Tatyana; Basok, Stepan; Kulygina, Catherine; Lyapunov, Alexander; Lukyanenko, Nikolay
Synthesis, 2002 , # 15 p. 2266 - 2270
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in toluene 16 h; Heating;
参考文献
Bogaschenko, Tatyana; Basok, Stepan; Kulygina, Catherine; Lyapunov, Alexander; Lukyanenko, Nikolay
Synthesis, 2002 , # 15 p. 2266 - 2270
反应条件
sodium hydroxide; tetra-(n-butyl)ammonium iodide in toluene 16 h; Heating;
参考文献
Synthesis, , # 15 p. 2266 - 2270
反应条件
nitric acid in acetic acid; benzene
T=20 - 22°C;
参考文献
Abakumova, N. I.; Kolenko, I. K.; Kodess, M. I.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1305 - 1307
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 7 p. 1495 - 1498
反应条件
nitric acid in chloroform
0.5 h; Ambient temperaturevar.solvents; Product distribution;
参考文献
Abakumova, N. I.; Kolenko, I. K.; Kodess, M. I.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 1305 - 1307
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 7 p. 1495 - 1498
反应条件
pyridine in dichloromethane
T=20°C; 16 h;
参考文献
Caldarelli, Sergio A.; Duckert, Jean-Frederic; Wein, Sharon; Calas, Michele; Perigaud, Christian; Vial, Henri; Peyrottes, Suzanne
ChemMedChem, 2010 , vol. 5, # 7 p. 1102 - 1109
反应条件
1: 69 percent / sodium hydroxide / H2O; tetrahydrofuran / 3 h / 0 °C
2: 32 percent / sodium hydride / tetrahydrofuran / 45 h / Heating
3: 71 percent / p-toluenesulfonic acid; hydrogen / palladium/charcoal / ethanol / 6 h / Heating
View Scheme
参考文献
Luk'yanenko; Basok; Kulygina, E. Yu.; Bogashchenko, T. Yu.; Yakovenko
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 10 p. 1345 - 1352
Zh. Org. Khim., 2012 , vol. 48, # 10 p. 1350 - 1357,8
