2,9-二氮杂螺[5.5]十一烷-2-甲酸叔丁酯合成路线 （共 4 条）
反应条件
ammonia in methanol T=110°C; P=60804.1 Torr; Autoclave;
参考文献
WO2014/15495 A1, ;
Page/Page column 36 ;
反应条件
1: Dess-Martin periodane / dichloromethane 2: N-benzyl-trimethylammonium hydroxide / water; 1,4-dioxane 3: hydrogen; palladium on activated charcoal; hydrogenchloride / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 565 - 570
反应条件
1: sodium hydroxide; water / 50 °C 2: ammonia / methanol / 110 °C / 60804.1 Torr / |Autoclave View Scheme
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C 2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 4 h 2.2: -78 °C 3.1: sodium hydroxide; water / 50 °C 4.1: ammonia / methanol / 110 °C / 60804.1 Torr / |Autoclave View Scheme
