2,4-二氯-6-溴喹唑啉合成路线 （共 14 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate Heating;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-5-bromo-benzonitrile in chlorobenzene T=120°C; 10 h;
参考文献
Li, Zhenhua; Wu, Danli; Zhong, Weihui
Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
反应条件
N,N-dimethyl-aniline; trichlorophosphate 16 h; Reflux;
参考文献
WO2009/143058 A1, ;
Page/Page column 69 ;
反应条件
in acetonitrile T=130°C; 12 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: 1.5 h / 200 °C 2: POCl3; N,N-dimethylaniline / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300
反应条件
1: dimethylformamide / 0.5 h / 100 °C 2: aq. K2CO3 / methanol / 12 h / 20 °C 3: 46 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: dimethylformamide / 0.5 h / 20 °C 2: dimethylformamide / 0.5 h / 100 °C 3: aq. K2CO3 / methanol / 12 h / 20 °C 4: 46 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: ICl / dimethylformamide / 0.5 h / 20 °C 2: dimethylformamide / 0.5 h / 20 °C 3: dimethylformamide / 0.5 h / 100 °C 4: aq. K2CO3 / methanol / 12 h / 20 °C 5: 46 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: 78.5 percent / 2 h / 180 - 210 °C 2: 95.2 percent / POCl3, N,N-dimethylaniline / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
反应条件
ammonia in N,N-dimethyl-formamide T=35 - 40°C; 0.666667 h;
参考文献
Pharmaceutical Chemistry Journal, , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, , vol. 21, # 7 p. 802 - 807
