2-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸合成路线 （共 3 条）
→
102416-29-52-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸
反应条件
triethylamine in pyridine T=90 - 100°C; 7 h;
参考文献
Shibata; Takahashi; Yano; Harada; Saito; Tamura; Kumagai; Hirabayashi; Yamamoto; Nagata
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1910 - 1918
→
102416-29-52-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸
反应条件
1: 165 mg / NaAlH2(OCH2CH2OCH3)2 / tetrahydrofuran; toluene / 1 h / 60 °C 2: 90 percent / conc. HCl / CHCl3 / 0.17 h / Ambient temperature 3: 21 g / triethylamine / pyridine / 7 h / 90 - 100 °C View Scheme
参考文献
Shibata; Takahashi; Yano; Harada; Saito; Tamura; Kumagai; Hirabayashi; Yamamoto; Nagata
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1910 - 1918
→
102416-29-52-[[(3S,4aR,6aR,6bS,8aS,11S,14aR,14bS)-11-[(2-羧基苯甲酰基)氧基甲基]-4,4,6a,6b,8a,11,14b-七甲基-1,2,3,4a,5,6,7,8,9,10,12,14a-十二氢苉-3-基]氧羰基]苯甲酸
反应条件
1: 90 percent / conc. HCl / CHCl3 / 0.17 h / Ambient temperature 2: 21 g / triethylamine / pyridine / 7 h / 90 - 100 °C View Scheme
参考文献
Shibata; Takahashi; Yano; Harada; Saito; Tamura; Kumagai; Hirabayashi; Yamamoto; Nagata
Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1910 - 1918
