5-甲氧基苯并呋喃-2-甲酸合成路线 （共 13 条）
反应条件
potassium hydroxide in ethanol 0.75 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 27, # 5 p. 570 - 576
反应条件
1: K2CO3 / butan-2-one 2: aq. KOH / ethanol View Scheme
参考文献
Journal of Materials Chemistry, , vol. 11, # 11 p. 2759 - 2772
反应条件
potassium carbonate; butanone Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;
参考文献
Biochemical Journal, , vol. 66, p. 188,191
Journal of the American Chemical Society, , vol. 73, p. 872
反应条件
1: 71 percent / diisobutylaluminum hydride / tetrahydrofuran / 4 h / Ambient temperature 2: 60 percent / MnO2 / ethyl acetate / 3 h / Ambient temperature View Scheme
参考文献
Lau, Cheuk K.; Belanger, Patrice C.; Dufresne, Claude; Scheigetz, John; Therien, Michael; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1299 - 1318
反应条件
lithium diisopropyl amide; methyl iodide T=-90°C;
参考文献
Buttery, Cheryl D.; Knight, David W.; Nott, Andrew P.
Tetrahedron Letters, 1982 , vol. 23, # 40 p. 4127 - 4130
反应条件
lithium diisopropyl amide in tetrahydrofuran 1.) < -90 deg C, 0.25 h, 2.) warmed to room temperature; Yields of byproduct given;
参考文献
Buttery, Cheryl D.; Knight, David W.; Nott, Andrew P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2839 - 2843
参考文献
Birkinshaw et al.
Biochemical Journal, 1957 , vol. 66, p. 188,191
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Tanaka
Journal of the American Chemical Society, 1951 , vol. 73, p. 872
反应条件
bromine in carbon disulfide 24 h; Heating;
参考文献
Masayuki, Inoue; Carson, Mattew W.; Frontier, Alison J.; Danishefsky, Samuel J.
Journal of the American Chemical Society, 2001 , vol. 123, # 9 p. 1878 - 1889
反应条件
1: With thionyl chloride in benzene 2: With ammonia in tetrahydrofuran
参考文献
Friedman; Toyne; Goodby; Hird
Journal of Materials Chemistry, 2001 , vol. 11, # 11 p. 2759 - 2772
反应条件
1: boron tribromide / dichloromethane / 0.75 h / -15 °C 2: thionyl chloride / 1 h / 80 °C View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/157270 A1, 2008 ;
