3,4-二甲氧基苯基氨基甲酸叔丁酯合成路线 （共 9 条）
反应条件
Cu(BF4)2 T=30 - 33°C; 0.5 h;
参考文献
Chankeshwara, Sunay V.; Chakraborti, Asit K.
Tetrahedron Letters, 2006 , vol. 47, # 7 p. 1087 - 1091
反应条件
hydrogenchloride; sodium hydroxide in tetrahydrofuran; dichloromethane; water
参考文献
Ortho Pharmaceutical Corporation
Patent: US4617417 A1, 1986 ;
反应条件
1: N-Boc-3,4-dimethoxylaniline With n-butyllithium in tetrahydrofuran T=-78 - -10°C; 2 h; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran T=20°C; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; water pH=1 - 2; Inert atmosphere;
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
Location in patent: Page/Page column 192 ;
反应条件
tert.-butyl lithium 1.) hexane, THF, -60 to -20 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bengtsson, Stefan; Hoegberg, Thomas
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4549 - 4553
反应条件
tert.-butyl lithium 1.) hexane, THF, -60 to -20 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bengtsson, Stefan; Hoegberg, Thomas
Journal of Organic Chemistry, 1989 , vol. 54, # 19 p. 4549 - 4553
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Reflux;
参考文献
New Journal of Chemistry, , vol. 36, # 11 p. 2188 - 2191
反应条件
1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -10 °C / |Inert atmosphere
1.2: 20 °C / |Inert atmosphere
1.3: pH 1 - 2 / |Inert atmosphere
2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
GLAXO GROUP LIMITED; SHIONOGI and CO., LTD.; LIAO, Xiangmin; PEARSON, Neil, David; PENDRAK, Israil; SANO, Masayuki
Patent: WO2013/52568 A1, 2013 ;
反应条件
tert.-butyl lithium
1.) THF, from -78 deg C to -20 deg C, 135 min 2.) a.) THF, from -78 deg C to RT, b.) RT, 2 h; Yield given. Multistep reaction;
参考文献
Saa, Carlos; Guitian, Enrique; Castedo, Luis; Suau, Rafael; Saa, Jose Manuel
Journal of Organic Chemistry, 1986 , vol. 51, # 14 p. 2781 - 2784
反应条件
[bis(acetoxy)iodo]benzene; silica gel; triethylamine
T=20°C; 6 h;
参考文献
Bodipati, Naganjaneyulu; Peddinti, Rama Krishna
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 23 p. 4549 - 4553
