3-溴-2-甲基-苯并[b]噻吩合成路线 （共 10 条）
反应条件
bromine in chloroform T=0°C; 2 h;
参考文献
Tetrahedron, , vol. 63, # 38 p. 9482 - 9487
反应条件
1: 3-bromo-benzo[b]-thiophene With lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=-78°C; 0.25 h; 2: methyl iodide in tetrahydrofuran; cyclohexane T=20°C; 1 h;
参考文献
WO2006/107784 A1, ;
Page/Page column 98 ;
WO 2006/107784 A1
反应条件
hydrogenchloride; n-butyllithium in diethyl ether; hexane
反应条件
n-butyllithium 1) THF, hexane, 30 min, -75 deg C, 2) 1h, -75 deg C, then r.t.;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 4 p. 1083 - 1090
反应条件
1: 3-bromo-2-methylbenzolt;bgt;thiophene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1.52778E-05 h; Flow microreactor system; 2: methyl iodide in tetrahydrofuran; hexane T=0°C; Flow microreactor system;
参考文献
Asai, Tatsuro; Takata, Atsushi; Ushiogi, Yousuke; Iinuma, Yoshiharu; Nagaki, Aiichiro; Yoshida, Jun-Ichi
Chemistry Letters, 2011 , vol. 40, # 4 p. 393 - 395
反应条件
1: 3-bromo-2-methylbenzolt;bgt;thiophene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2: 1,2,3,3,4,4,5,5-octafluorocyclopentene in tetrahydrofuran; hexane T=0°C; Further stages.;
参考文献
Ushiogi, Yousuke; Hase, Tomoyuki; Iinuma, Yoshiharu; Takata, Atsushi; Yoshida, Jun-Ichi
Chemical Communications, 2007 , # 28 p. 2947 - 2949
反应条件
1: 3-bromo-2-methylbenzolt;bgt;thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: 1-(2-methylbenzo[b]thiophen-3-yl)-2,3,3,4,4,5,5-heptafluorocyclopentane in tetrahydrofuran; hexane T=-95 - 20°C;
参考文献
Yagi, Kyoko; Irie, Masahiro
Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 8 p. 1625 - 1628
反应条件
n-butyllithium in diethyl ether T=-78°C; Inert atmosphere;
参考文献
Edelsztein, Valeria C.; Jares-Erijman, Elizabeth A.; Spagnuolo, Carla C.; Di Chenna, Pablo H.; Muellen, Klaus
Journal of Materials Chemistry, 2012 , vol. 22, # 41 p. 21857 - 21861,5
反应条件
n-butyllithium
1) THF, hexane, -75 deg C, 2) -75 deg C, then r.t.;
参考文献
Iddon, Brian; Redhouse, Alan D.; Yat, Patrick N.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 4 p. 1083 - 1090
反应条件
1: 3-bromo-2-methylbenzolt;bgt;thiophene With n-butyllithium in tetrahydrofuran; hexane
T=0°C; 1.52778E-05 h; Flow microreactor system;
2: methyl iodide in tetrahydrofuran; hexane
T=0°C; Flow microreactor system;
参考文献
Asai, Tatsuro; Takata, Atsushi; Ushiogi, Yousuke; Iinuma, Yoshiharu; Nagaki, Aiichiro; Yoshida, Jun-Ichi
Chemistry Letters, 2011 , vol. 40, # 4 p. 393 - 395
