1-[3-[(1,2-二氢-2-甲基-1-氧代吡咯并[1,2-a]吡嗪)-3-基]丙基]胍合成路线 （共 8 条）
反应条件
1: 82 percent / KH / tetrahydrofuran / 0 °C 2: 63 percent / NaBH4, CoCl2 / methanol / Ambient temperature 3: 88 percent / toluene / 24 h / Heating 4: 80 percent / KH / tetrahydrofuran / Ambient temperature 5: 76 percent / KH / dimethylformamide 6: 72 percent / NaBH4 / methanol / 12 h 7: 1.) MsCl, Et3N, 2.) LiBr / 1.) CH2Cl2, -60 deg C, 15 min, 2.) THF, -60 to -40 deg C, 30 min 8: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 9: 62 percent / NaBH4, CoCl2 / methanol 10: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 1.) MsCl, Et3N, 2.) LiBr / 1.) CH2Cl2, -60 deg C, 15 min, 2.) THF, -60 to -40 deg C, 30 min 2: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 3: 62 percent / NaBH4, CoCl2 / methanol 4: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 2: 62 percent / NaBH4, CoCl2 / methanol 3: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 62 percent / NaBH4, CoCl2 / methanol 2: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 76 percent / KH / dimethylformamide 2: 72 percent / NaBH4 / methanol / 12 h 3: 1.) MsCl, Et3N, 2.) LiBr / 1.) CH2Cl2, -60 deg C, 15 min, 2.) THF, -60 to -40 deg C, 30 min 4: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 5: 62 percent / NaBH4, CoCl2 / methanol 6: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 72 percent / NaBH4 / methanol / 12 h 2: 1.) MsCl, Et3N, 2.) LiBr / 1.) CH2Cl2, -60 deg C, 15 min, 2.) THF, -60 to -40 deg C, 30 min 3: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 4: 62 percent / NaBH4, CoCl2 / methanol 5: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
1: 80 percent / KH / tetrahydrofuran / Ambient temperature 2: 76 percent / KH / dimethylformamide 3: 72 percent / NaBH4 / methanol / 12 h 4: 1.) MsCl, Et3N, 2.) LiBr / 1.) CH2Cl2, -60 deg C, 15 min, 2.) THF, -60 to -40 deg C, 30 min 5: 1.) n-BuLi, 2.) CuBr*Me2S / 1.) -78 deg C, 30 min, 2.) -78 to -40 deg C, 30 min, 3.) -40 to -20 deg C, 1 h 6: 62 percent / NaBH4, CoCl2 / methanol 7: 2M NaOH / 48 h / Ambient temperature View Scheme
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
反应条件
sodium hydroxide 48 h; Ambient temperature;
参考文献
Brimble, Margaret A.; Rowan, Daryl R.
Journal of the Chemical Society, Chemical Communications, 1988 , # 14 p. 978 - 979
