3-氧代-3-(n-叔丁氧基羰基-氮杂啶-3-基)丙酸乙酯合成路线 (共 1 条)
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; 3-carboxyazetidine-1-carboxylic acid tert-butyl ester With 4-(N,N-dimethlyamino)pyridine; 1,1'-carbonyldiimidazole in dichloromethane T=0 - 20°C; 2: ethanol 6 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/57940 A1, 2008 ;
Location in patent: Page/Page column 61-62 ;