1: With tributyl-amine in dichloromethane T=-20°C; 2: With trifluoroacetic acid in dichloromethane

Multi-step reaction with 7 steps 1.1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium chloride; sodium hypochlorite / water; acetonitrile; aq. phosphate buffer / 35 °C / pH 6 - 72.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h / 20 °C2.2: 24 h / 20 °C3.1: sulfur trioxide pyridine complex / pyridine / 2 h / 0 °C3.2: 2 h / |Reflux4.1: hydrogen; 5 palladium on charcoal / water; methanol / 1 h / 2585.81 Torr5.1: pyridine / 1.5 h / 0 - 20 °C6.1: potassium dihydrogenphosphate / water; dichloromethane / 1 h / 0 - 5 °C7.1: formic acid / dichloromethane / 0 - 20 °C