1-羟基-2-甲基丙烷-2-氨基甲酸叔丁酯合成路线 （共 19 条）
反应条件
hydrogenchloride; sodium hydrogencarbonate; rhodium (II) acetate in methanol; lithium hydroxide; anhydrous dichloroethane; water
参考文献
Novo Nordisk A/S
Patent: US5977178 A1, 1999 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate; rhodium (II) acetate in methanol; lithium hydroxide; anhydrous dichloroethane; water
参考文献
Novo Nordisk A/S
Patent: US5977178 A1, 1999 ;
反应条件
1: [Rh2(OAc)4] / 1,2-dichloro-ethane / 8 h / Heating 2: LiOH / methanol; H2O View Scheme
参考文献
Peschke, Bernd; Ankersen, Michael; Sehested Hansen, Birgit; Kruse Hansen, Thomas; Langeland Johansen, Nils; Lau, Jesper; Madsen, Kjeld; Petersen, Hans; Thogersen, Henning; Watson, Brett
European Journal of Medicinal Chemistry, 1999 , vol. 34, # 5 p. 363 - 380
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 24 h; Heating; Yield given;
参考文献
BIOCOPEA LIMITED; BANNISTER, Robin Mark
Patent: WO2010/103312 A1, 2010 ;
Location in patent: Page/Page column 10 ;
反应条件
1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 20 °C 2: hydrazine hydrate / ethanol; dichloromethane / 20 °C View Scheme
参考文献
Hunt, Thomas; Atherton-Watson, Hazel C.; Collingwood, Stephen P.; Coote, Kevin J.; Czarnecki, Sarah; Danahay, Henry; Howsham, Catherine; Hunt, Peter; Paisley, Derek; Young, Alice
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 8 p. 2877 - 2879
反应条件
trifluoroacetic acid in dichloromethane
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Patent: WO2005/115150 A2, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/115150 A2
反应条件
pyridine-SO3 complex; triethylamine in dimethyl sulfoxide 0.5 h; Ambient temperature;
参考文献
Seki, Toshimi; Nakao, Tomio; Masuda, Takeshi; Hasumi, Kohichi; Gotanda, Kotaro; Ishimori, Tsutomu; Honma, Seijiro; Minami, Nobuyoshi; Shibata, Kenyu; Yasuda, Kikuo
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 11 p. 2061 - 2069
反应条件
sodium hydrogencarbonate; triethylamine in dichloromethane; dimethyl sulfoxide
参考文献
Novo Nordisk A/S
Patent: US6013658 A1, 2000 ;
参考文献
Braghiroli, Daniela; Di Bella, Maria
Tetrahedron Letters, 1996 , vol. 37, # 40 p. 7319 - 7322
