1025373-45-8合成路线 （共 20 条）
反应条件
1: 1,3-cylohexanedione With sodium hexamethyldisilazane in tetrahydrofuran T=-50°C; 2: trifluoromethanesulfonic acid anhydride in tetrahydrofuran T=-50 - 20°C; 3: With water; sodium hydrogencarbonate in tetrahydrofuran T=-30°C;
参考文献
AMGEN INC.
Patent: US2010/160280 A1, 2010 ;
Location in patent: Page/Page column 154; 155 ;
反应条件
2,6-dimethylpyridine in dichloromethane T=0°C; 2 h;
参考文献
Betschart, Claudia; Lerchner, Andreas; Machauer, Rainer; Rueger, Heinrich; Tintelnot-Blomley, Marina; Veenstra, Siem Jacob
Patent: US2008/132477 A1, 2008 ;
Location in patent: Page/Page column 30 ;
反应条件
triethylamine in dichloromethane T=-78 - 20°C; Inert atmosphere;
参考文献
US2011/230495 A1, ;
Page/Page column 17 ;
参考文献
Wyeth
Patent: US2008/45556 A1, 2008 ;
Location in patent: Page/Page column 41 ;
反应条件
pyridine in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
pyridine in dichloromethane T=0 - 20°C; 16 h; Product distribution / selectivity;
参考文献
N.V. Organon
Patent: US2010/324021 A1, 2010 ;
Location in patent: Page/Page column 26-27 ;
US 20100324021 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C; 2 - 18 h;
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
Location in patent: Paragraph 0288 ;
反应条件
pyridine in dichloromethane T=0°C; 0.416667 h;
参考文献
Merz Pharma GmbH and Co. KGaA; The designation of the inventor has not yet been filed
Patent: EP2650284 A1, 2013 ;
Location in patent: Paragraph 0248 ;
反应条件
1: ethyl 2-oxo-cyclopentanecarboxylate With sodium hydride; trifluoromethanesulfonic acid anhydride in diethyl ether; mineral oil T=0°C; 0.166667 h; Inert atmosphere; 2: trifluoromethanesulfonic acid anhydride in diethyl ether; mineral oil T=0°C; 1 h;
参考文献
Frackenpohl, Jens; Müller, Thomas; Heinemann, Ines; Von Koskull-döring, Pascal; Rosinger, Christopher Hugh; Häuser-Hahn, Isolde; Hills, Martin Jeffrey
Patent: US2014/80704 A1, 2014 ;
Location in patent: Paragraph 0221 ;
反应条件
1: With pyridine in dichloromethane T=0°C; 1.5 h; 2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
SHIONOGI and CO., LTD.
Patent: EP1422218 A1, 2004 ;
Location in patent: Page 157; 158; 225 ;
