1-乙基-4-(3-甲氧基苯基)-3,6-二氢-2H-吡啶合成路线 （共 4 条）
反应条件
phosphoric acid T=70 - 80°C; 3 h;
参考文献
Zimmerman; Cantrell; Reel; Hemrick-Luecke; Fuller
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1517 - 1520
反应条件
sodium hydroxide in water; toluene
参考文献
Pfizer Inc.
Patent: US5972962 A1, 1999 ;
反应条件
1: 1.) n-butyllithium / 1.) THF, -78 deg C, 30 min, 2.) THF, -20 deg C, 2 h 2: 90 percent / 85percent aq. phosphoric acid / 3 h / 70 - 80 °C View Scheme
参考文献
Zimmerman; Cantrell; Reel; Hemrick-Luecke; Fuller
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1517 - 1520
反应条件
1: 1.) n-butyllithium / 1.) THF, -78 deg C, 30 min, 2.) THF, -20 deg C, 2 h 2: 90 percent / 85percent aq. phosphoric acid / 3 h / 70 - 80 °C View Scheme
参考文献
Zimmerman; Cantrell; Reel; Hemrick-Luecke; Fuller
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1517 - 1520
