3-甲基-2-苯基-1H-吲哚合成路线 （共 60 条）
反应条件
1: 48 percent / Pd(OAc)2 / acetic acid / 14 h / Heating
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Itahara, Toshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 5 p. 254 - 255
反应条件
1: 48 percent / Pd(OAc)2 / acetic acid / 14 h / Heating
2: NaOH / ethanol; H2O / Heating
View Scheme
参考文献
Itahara, Toshio
Journal of the Chemical Society, Chemical Communications, 1981 , # 5 p. 254 - 255
反应条件
1: NaBH4 / methanol / 2.5 h / Ambient temperature
2: gaseous HCl / ethanol / 2.5 h / Ambient temperature
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参考文献
Berti, Corrado; Greci, Lucedio; Poloni, Marino; Andreetti, Giovanni Dario; Bocelli, Gabriele; Sgarabotto, Paolo
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 339 - 346
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 5 h / 0 - 20 °C / |Inert atmosphere
2: diisobutylaluminium hydride / toluene / 20 °C / |Inert atmosphere
3: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere
4: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C
5: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling
6: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Nguyen, Quyen; Nguyen, Tuyen; Driver, Tom G.
Journal of the American Chemical Society, 2013 , vol. 135, # 2 p. 620 - 623
反应条件
1: diisobutylaluminium hydride / toluene / 20 °C / |Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere
3: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C
4: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling
5: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Nguyen, Quyen; Nguyen, Tuyen; Driver, Tom G.
Journal of the American Chemical Society, 2013 , vol. 135, # 2 p. 620 - 623
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / |Inert atmosphere
2: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C
3: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling
4: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Nguyen, Quyen; Nguyen, Tuyen; Driver, Tom G.
Journal of the American Chemical Society, 2013 , vol. 135, # 2 p. 620 - 623
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C
2: 1,1-dimethylnitroethane; trimethylsilylazide / acetonitrile / 2 h / 20 °C / |Inert atmosphere; |Cooling
3: FeBr2 / toluene / 16 h / 140 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Nguyen, Quyen; Nguyen, Tuyen; Driver, Tom G.
Journal of the American Chemical Society, 2013 , vol. 135, # 2 p. 620 - 623
反应条件
1: sodium hydroxide / tetrahydrofuran / 0.5 h / |Inert atmosphere
2: [{(η5-C5Me5)RhCl}2(μ-Cl)2]; caesium acetate; acetic acid / 1,2-dichloro-ethane / 16 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Zhao, Dongbing; Shi, Zhuangzhi; Glorius, Frank
Angewandte Chemie - International Edition, 2013 , vol. 52, # 47 p. 12426 - 12429
Angew. Chem., 2013 , vol. 125, # 47 p. 12652 - 12656,4
反应条件
1: toluene / 5 h / Heating
2: ethane-1,2-diol / 10 h / Heating
View Scheme
参考文献
Robinson, Brian; Khan, Munir I.; Shaw, Mark J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2265 - 2268
反应条件
T=800°C; P=0.001 - 0.01 Torr; approximate contact time: 0.002-0.03 s;
参考文献
Ohsawa, Akio; Kawaguchi Takayuki; Igeta Hiroshi
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4352 - 4358
