2-氨基-4-异丙基-5-溴噻唑合成路线 (共 3 条)
反应条件
1: With bromine in chloroform T=20°C; 60 h; 2: With water; sodium hydrogencarbonate in chloroform
参考文献
WO2008/55840 A1, ;
Page/Page column 62; 63 ;
WO 2008/055840 A1
反应条件
1.1: 1.5 h / Reflux 1.2: pH 12 2.1: bromine / chloroform / 60 h / 20 °C View Scheme
参考文献
US2012/22067 A1, ;
US 20120022067 A1
反应条件
1: With phosphoric acid; nitric acid; sodium nitrite in water T=-5°C; 0.833333 h; 2: With hypophosphorous acid in water T=-5 - 20°C; 20.5 h; 3: With sodium hydroxide; water T=0°C;
参考文献
WO2008/55840 A1, ;
Page/Page column 62; 63 ;
WO 2008/055840 A1