1: 95 percent / pyridine / 3 h / Ambient temperature 2: 97 percent / H2 / Lindlar / ethyl acetate / 24 h / Ambient temperature 3: 8 h / 0 °C / asymmetric hydrolysis with Lipase P, acetate buffer, pH 5 4: H2 / PtO2 / ethyl acetate / 2 h / 760 Torr / Ambient temperature 5: pyridine / 12 h / 0 °C 6: LiAlH4 / diethyl ether / 12 h / Heating View Scheme

pyridine 3 h; Ambient temperature;

Multi-step reaction with 4 steps 1: 95 percent / pyridine / 3 h / Ambient temperature2: 97 percent / H2 / Lindlar / ethyl acetate / 24 h / Ambient temperature3: 8 h / 0 °C / asymmetric hydrolysis with Lipase P, acetate buffer, pH 54: H2 / PtO2 / ethyl acetate / 2 h / 760 Torr / Ambient temperature