sodium hydride in tetrahydrofuran T=20°C; Tosylation; 1 h;

1.1: 317 mg / zinc borohydride / diethyl ether / 0.5 h / 0 °C 2.1: 87 percent / mesyl chloride; N,N-diisopropylethylamine / CH2Cl2 / 0.83 h / 0 - 20 °C 3.1: methylmagnesium iodide / diethyl ether; tetrahydrofuran / 1 h / -10 - 20 °C 3.2: diethyl ether; tetrahydrofuran / 2 h / -10 - 20 °C 4.1: 99 percent / sodium hydride / tetrahydrofuran / 1 h / 20 °C View Scheme

1.1: 87 percent / mesyl chloride; N,N-diisopropylethylamine / CH2Cl2 / 0.83 h / 0 - 20 °C 2.1: methylmagnesium iodide / diethyl ether; tetrahydrofuran / 1 h / -10 - 20 °C 2.2: diethyl ether; tetrahydrofuran / 2 h / -10 - 20 °C 3.1: 99 percent / sodium hydride / tetrahydrofuran / 1 h / 20 °C View Scheme

1.1: methylmagnesium iodide / diethyl ether; tetrahydrofuran / 1 h / -10 - 20 °C 1.2: diethyl ether; tetrahydrofuran / 2 h / -10 - 20 °C 2.1: 99 percent / sodium hydride / tetrahydrofuran / 1 h / 20 °C View Scheme

n-butyllithium in tetrahydrofuran; hexane T=-78 - 23°C; 12 h;

暂无反应条件数据

1: Et3N, 4 Angstroem molecular sieves / CH2Cl2 / 48 h / Ambient temperature 2: 95 percent / NaBH3CN / ethanol / 0.17 h / 0 °C 3: 80 percent / TiCl4 / benzene / 10 h / Heating 4: 90 percent / NaOEt / ethanol / 0.5 h / 0 °C View Scheme

N-methylamine hydrochloride; sodium acetate in methanol T=20°C; 38 h;

1: 90 percent / sodium acetate; methylamine hydrochloride / methanol / 38 h / 20 °C 2: 31 percent / NaBH4 / methanol; dimethylformamide / 0.25 h View Scheme