反应条件
1: NaH / dimethylformamide / 15.5 h / 80 °C
2: p-TsOH / methanol / 4 h / Ambient temperature
3: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 30 min, 2.) CH2Cl2, from -78 deg C to RT
4: NH2OSO3H / H2O / 2.17 h / 50 °C
View Scheme
参考文献
Kaku, Yumiko; Tsuruoka, Akihiko; Kakinuma, Hiroyuki; Tsukada, Itaru; Yanagisawa, Manabu; Naito, Toshihiko
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 7 p. 1125 - 1129
