(4-甲氧基-3-甲基-2-吡啶基)甲基乙酸酯合成路线 （共 10 条）
反应条件
acetic acid T=120°C;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1.1: 80 percent / POCl3 / CH2Cl2; dimethylformamide / 12 h / 25 °C 2.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 2.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 3.1: 5 h / 120 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
1.1: NaOH / dimethylsulfoxide / 1 h / 60 °C 1.2: 15 g / dimethylsulfoxide / 4 h / 60 °C 2.1: 5 h / 120 °C View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
反应条件
1: 53 percent / conc. H2SO4, 65percent HNO3 / 20 h / 95 °C 2: 99 percent / K2CO3 / 2 h / Heating 3: 4 h / 100 °C View Scheme
参考文献
Kuhler; Fryklund; Bergman; Weilitz; Lee; Larsson
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4906 - 4916
反应条件
sodium hydroxide in methanol T=25°C; 2 h;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: 2-acetoxymethyl-4-methoxy-3-methylpyridine With thionyl chloride in chloroform 1 h; Reflux; 2: 2-mercaptobenzoimidazole With sodium methylate in methanol 1 h; Reflux;
参考文献
Arigen, Pharmaceuticals, Inc.
Patent: EP2103608 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
1: NaOH / H2O / 1 h / 25 °C 2: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 3: 88 percent / NaOH / H2O / 3 h / 25 °C View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
1: NaOH / H2O / 1 h / 25 °C 2: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C 3: 88 percent / NaOH / H2O / 3 h / 25 °C 4: 57 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -15 - -10 °C View Scheme
参考文献
Pharmazie, , vol. 60, # 11 p. 814 - 818
反应条件
1: 10percent aq. HCl / 1.5 h / 90 °C 2: SOCl2 / CH2Cl2 / 0 °C View Scheme
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
反应条件
1: NaOH / H2O / 1 h / 25 °C
2: 90 percent / SOCl2 / CH2Cl2 / 1 h / 25 °C
View Scheme
参考文献
Sharada; Satyanarayana Reddy; Sammaiah; Sumalatha
Asian Journal of Chemistry, 2013 , vol. 25, # 14 p. 7959 - 7966
