trichlorophosphate in chloroform 15 h; Heating;

1: 40percent peracetic acid / 3 h / 90 °C 2: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h 3: 65 percent / H2, conc. HCl / 10percent Pd/C / methanol / 760 Torr 4: 83 percent / 15 h / 90 °C 5: 73 percent / POCl3 / toluene / 15 h / 90 °C 6: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 7: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 8: SOCl2 / 0.5 h / Heating 9: NH3 (gas) / CH2Cl2 / 15 h 10: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: 1.) dimethyl sulfate / 1.) toluene, 90 deg C, 3 h, 2.) water, 0 deg C, 24 h 2: 65 percent / H2, conc. HCl / 10percent Pd/C / methanol / 760 Torr 3: 83 percent / 15 h / 90 °C 4: 73 percent / POCl3 / toluene / 15 h / 90 °C 5: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 6: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 7: SOCl2 / 0.5 h / Heating 8: NH3 (gas) / CH2Cl2 / 15 h 9: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: 83 percent / 15 h / 90 °C 2: 73 percent / POCl3 / toluene / 15 h / 90 °C 3: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 4: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 5: SOCl2 / 0.5 h / Heating 6: NH3 (gas) / CH2Cl2 / 15 h 7: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: 65 percent / H2, conc. HCl / 10percent Pd/C / methanol / 760 Torr 2: 83 percent / 15 h / 90 °C 3: 73 percent / POCl3 / toluene / 15 h / 90 °C 4: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 5: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 6: SOCl2 / 0.5 h / Heating 7: NH3 (gas) / CH2Cl2 / 15 h 8: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 2: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 3: SOCl2 / 0.5 h / Heating 4: NH3 (gas) / CH2Cl2 / 15 h 5: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: 73 percent / POCl3 / toluene / 15 h / 90 °C 2: 85 percent / H2, conc. HCl / 10percent Pd/C / ethanol / 4 h / 60 °C / 2068.6 Torr 3: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 4: SOCl2 / 0.5 h / Heating 5: NH3 (gas) / CH2Cl2 / 15 h 6: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

potassium tert-butylate in tetrahydrofuran 2 h; Ambient temperature;

1: 95 percent / 1 N NaOH / ethanol / 3 h / Heating 2: SOCl2 / 0.5 h / Heating 3: NH3 (gas) / CH2Cl2 / 15 h 4: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme

1: SOCl2 / 0.5 h / Heating 2: NH3 (gas) / CH2Cl2 / 15 h 3: 85 percent / POCl3 / CHCl3 / 15 h / Heating View Scheme