反应条件
1: copper(l) iodide; triethylamine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex / N,N-dimethyl-formamide / 12 h / 60 °C / |Inert atmosphere
2: hydrogenchloride / tetrahydrofuran; water / 12 h / 40 °C
3: sodium tetrahydroborate / tetrahydrofuran / 2 h / -25 °C
4: methanol; lithium hydroxide hydrate / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1893 - 1901