反应条件
1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C
2: thionyl chloride / 1 h
3: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C
4: water; sodium hydroxide / ethanol / 2 h / Reflux
5: 1 h / 180 °C
6: n-butyllithium / tetrahydrofuran; hexane / -78 °C
7: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.5 h / 0 °C
View Scheme
参考文献
Xue, Chu-Biao; Chen, Lihua; Cao, Ganfeng; Zhang, Ke; Wang, Anlai; Meloni, David; Glenn, Joseph; Anand, Rajan; Xia, Michael; Kong, Ling; Huang, Taisheng; Feng, Hao; Zheng, Changsheng; Li, Mei; Galya, Laurine; Zhou, Jiacheng; Shin, Niu; Baribaud, Fredric; Solomon, Kim; Scherle, Peggy; Zhao, Bitao; Diamond, Sharon; Emm, Tom; Keller, Douglas; Contel, Nancy; Yeleswaram, Swamy; Vaddi, Kris; Hollis, Gregory; Newton, Robert; Friedman, Steven; Metcalf, Brian
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 9 p. 483 - 487