反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.333333 h; 2: 2-(dimethylamino-methyleneamino)-5-ethoxy-4-methoxy-benzoic acid methyl ester in tetrahydrofuran; hexane T=-78°C; Addition; 1 h; 3: With acetic acid in tetrahydrofuran; hexane T=-78 - 25°C; Cyclization; Further stages.;
参考文献
Wissner; Berger; Boschelli; Brawner Floyd Jr.; Greenberger; Gruber; Johnson; Mamuya; Nilakantan; Reich; Shen; Tsou; Upeslacis; Yu Fen Wang; Wu; Ye; Zhang
Journal of Medicinal Chemistry, 2000 , vol. 43, # 17 p. 3244 - 3256