6-氯-4-(2-环丙基乙炔基)-8-[[(叔丁基)二甲基硅烷基]氧基]-1,4-二氢-4-(三氟甲基)-2H-3,1-苯并恶嗪-2-酮合成路线 （共 8 条）
反应条件
N-ethyl-N,N-diisopropylamine in toluene T=-25 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: SnCl2; EtOH / Heating 2: NEt3 / CH2Cl2 3: s-BuLi / tetrahydrofuran / -20 - 0 °C 4: aq. HCl / 1,2-dimethoxy-ethane / Heating 5: BBr3 / CH2Cl2 6: imidazole / dimethylformamide / 0 °C 7: 76 percent / tetrahydrofuran; hexane / -20 °C 8: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: NEt3 / CH2Cl2 2: s-BuLi / tetrahydrofuran / -20 - 0 °C 3: aq. HCl / 1,2-dimethoxy-ethane / Heating 4: BBr3 / CH2Cl2 5: imidazole / dimethylformamide / 0 °C 6: 76 percent / tetrahydrofuran; hexane / -20 °C 7: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating 3: BBr3 / CH2Cl2 4: imidazole / dimethylformamide / 0 °C 5: 76 percent / tetrahydrofuran; hexane / -20 °C 6: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: BBr3 / CH2Cl2 2: imidazole / dimethylformamide / 0 °C 3: 76 percent / tetrahydrofuran; hexane / -20 °C 4: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: imidazole / dimethylformamide / 0 °C 2: 76 percent / tetrahydrofuran; hexane / -20 °C 3: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: 76 percent / tetrahydrofuran; hexane / -20 °C 2: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran 2: chiral phase SCFC;
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
