5-羟基-4-氮杂吲哚-3-甲醛合成路线 （共 3 条）
反应条件
hydrogen bromide in acetic acid T=100°C; 2 h;
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
1: 2.) H2 / 2.) Pd/C / 1.) reflux, 3 h, 2.) toluene 2: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min 3: 94 percent / HBr / acetic acid / 2 h / 100 °C View Scheme
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
1: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min 2: 94 percent / HBr / acetic acid / 2 h / 100 °C View Scheme
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
