1: 28.8 g / fluoroboric acid, sodium nitrite / H2O
2: 7.6 g / warming, distillation
3: 1.) lithium / 1.) ether, 2 h
4: Cu-quinoline
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
1.1: hydrogenchloride / diethyl ether / 1.5 h / 0 - 10 °C
2.1: diethyl ether / 2 h / 170 °C
3.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C
3.2: 3 h / 20 °C
3.3: 16 h / 20 °C
View Scheme
参考文献
RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter Ronald
Patent: US2013/281397 A1, 2013 ;
