9-(2-乙酰氧基乙氧基甲基)鸟嘌呤合成路线 （共 26 条）
反应条件
methylamine T=80°C; 0.5 h;
参考文献
Tak, Rahul V.; Pal, Dhananjay; Gao, Hongwu; Dey, Surajit; Mitra, Ashim K.
Journal of Pharmaceutical Sciences, 2001 , vol. 90, # 10 p. 1505 - 1515
反应条件
2,4,6-trimethyl-pyridine; tetraethylammonium chloride; trichlorophosphate in acetonitrile 0.166667 h; Heating;
参考文献
Stimac; Kobe
Synthesis, 1990 , # 6 p. 461 - 464
反应条件
4-(N,N-dimethlyamino)pyridine in hexane; acetic anhydride; toluene
参考文献
Syntex (U.S.A.) Inc.
Patent: US5565565 A1, 1996 ;
反应条件
1: SIRC cell lysate; Dulbecco's Modified Phosphite-Buffer Saline / 34 °C / pH 7.4 2: 3.5 g / 4-dimethylaminopyridine; DCC / dimethylformamide / 66 h / 20 °C 3: aq. HCl; hydrogen / palladium on charcoal / methanol; tetrahydrofuran / 18 h / 20 °C View Scheme
参考文献
Tak, Rahul V.; Pal, Dhananjay; Gao, Hongwu; Dey, Surajit; Mitra, Ashim K.
Journal of Pharmaceutical Sciences, 2001 , vol. 90, # 10 p. 1505 - 1515
反应条件
1: SIRC cell lysate; Dulbecco's Modified Phosphite-Buffer Saline / 34 °C / pH 7.4 2: 3.5 g / 4-dimethylaminopyridine; DCC / dimethylformamide / 66 h / 20 °C View Scheme
参考文献
Tak, Rahul V.; Pal, Dhananjay; Gao, Hongwu; Dey, Surajit; Mitra, Ashim K.
Journal of Pharmaceutical Sciences, 2001 , vol. 90, # 10 p. 1505 - 1515
反应条件
1: 66 percent / Et4NCl, 2,4,6-trimethylpyridine, POCl3 / acetonitrile / 0.17 h / Heating
2: 88 percent / Et3N, HCO2H / Pd-C / acetone / 1 h / Heating
3: 81 percent / MeNH2/H2O / 0.17 h / Ambient temperature
View Scheme
参考文献
Stimac; Kobe
Synthesis, 1990 , # 6 p. 461 - 464
