7-氨基-3-[2-[4-(4-氟-2-氚苯甲酰基)哌啶-1-基]乙基]-1H-喹唑啉-2,4-二酮合成路线 （共 4 条）
反应条件
thiophene; tritium; palladium on activated charcoal; CaO in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Wouters, Walter; Janssen, Cornelus G. M.; Dun, Jacky Van; Thijssen, Jos B. A.; Laduron, Pierre M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1663 - 1668
反应条件
1: 22 percent / AlCl3 / 2 h / 80 °C 2: 78 percent / concd. HCl / 3 h / Heating 3: 15 percent / Na2CO3, KI / various solvent(s) / 20 h / Heating 4: 18 percent / T2, thiophene / 10percent Pd/C, calcium oxide / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Wouters, Walter; Janssen, Cornelus G. M.; Dun, Jacky Van; Thijssen, Jos B. A.; Laduron, Pierre M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1663 - 1668
反应条件
1: 22 percent / AlCl3 / 2 h / 80 °C 2: 78 percent / concd. HCl / 3 h / Heating 3: 15 percent / Na2CO3, KI / various solvent(s) / 20 h / Heating 4: 18 percent / T2, thiophene / 10percent Pd/C, calcium oxide / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Wouters, Walter; Janssen, Cornelus G. M.; Dun, Jacky Van; Thijssen, Jos B. A.; Laduron, Pierre M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1663 - 1668
反应条件
1: 15 percent / Na2CO3, KI / various solvent(s) / 20 h / Heating 2: 18 percent / T2, thiophene / 10percent Pd/C, calcium oxide / tetrahydrofuran / 18 h / Ambient temperature View Scheme
参考文献
Wouters, Walter; Janssen, Cornelus G. M.; Dun, Jacky Van; Thijssen, Jos B. A.; Laduron, Pierre M.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1663 - 1668
