反应条件
1: imidazole / 1,2-dimethoxy-ethane / 20 h / 0 - 20 °C 2: 92 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, HOBt, Et3N / dimethylformamide / 18 h / 0 - 20 °C 3: 69 percent / 8N HCl / propan-2-ol / 6 h / Ambient temperature View Scheme
参考文献
Dorsey; Levin; McDaniel; Vacca; Guare; Darke; Zugay; Emini; Schleif; Quintero; Lin; Chen -; Holloway; Fitzgerald; Axel; Ostovic; Anderson; Huff
Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3443 - 3451
