(R)-(-)-1-氨基茚满合成路线 （共 29 条）
反应条件
potassium hydroxide; butan-1-ol Inert atmosphereReflux;
参考文献
CHEMO IBERICA, S.A.; MARRAS, Giovanni; RASPARINI, Marcello; TUFARO, Roberto; CASTALDI, Graziano; GHISLERI, Diego
Patent: WO2010/49379 A1, 2010 ;
Location in patent: Page/Page column 41 ;
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Process Biochemistry, , vol. 48, # 10 p. 1488 - 1494
反应条件
hydrogen; acetic acid; palladium on activated charcoal in methanol T=25°C; P=3040 Torr; 62 h;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 24 p. 4369 - 4379
反应条件
1: With diacetone-2-ketogulonic acid in methanol; water RefluxResolution of racemate; 2: With sodium hydroxide in water T=25 - 30°C; 1 h; Product distribution / selectivity;
参考文献
GENERICS [UK] LIMITED; MYLAN DEVELOPMENT CENTRE PRIVATE LIMITED
Patent: WO2009/147430 A1, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
Alkaline protease in 3-methyl pentan-3-ol T=20°C; 0.25 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Nechab, Malek; El Blidi, Lahssen; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 21 p. 3917 - 3920
反应条件
borane-ammonia complex; water in dimethyl sulfoxide T=30°C; pH=7; 18 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Canadian Journal of Chemistry, , vol. 90, # 1 p. 39 - 45
反应条件
Vibrio fluvialis JS17; 2-oxo-propionic acid in phosphate buffer T=37°C; pH=7.0; Microbiological reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Bioscience, Biotechnology and Biochemistry, , vol. 65, # 8 p. 1782 - 1788
反应条件
1: TFA / toluene / 7 h / Heating 2: 25 percent / NaBH4 / ethanol / 48 h / -16 °C 3: H2, aq. acetic acid / 10 percent Pd/C / methanol / 62 h / 25 °C / 3040 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 9, # 24 p. 4369 - 4379
反应条件
water in dimethyl sulfoxide T=30°C; pH=7; 18 h; aq. phosphate bufferMicrobiological reactionEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Canadian Journal of Chemistry, , vol. 90, # 1 p. 39 - 45
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 72 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1759 - 1764
