(R)-(-)-1-氨基茚满合成路线 （共 29 条）
反应条件
(i) SOCl2, (ii) NaN3, (iii) aq. HCl; Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 88, # 10 p. 2233 - 2240
反应条件
2: (i) SOCl2, (ii) NaN3, (iii) aq. HCl View Scheme
参考文献
Journal of the American Chemical Society, , vol. 88, # 10 p. 2233 - 2240
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice 1.2: 20 °C 2.1: C9H16BNO / tetrahydrofuran / 24 h / 20 °C 2.2: 24 h / Reflux View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 5 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 24 h / Cooling with ice 2.2: 20 °C 3.1: C9H16BNO / tetrahydrofuran / 24 h / 20 °C 3.2: 24 h / Reflux View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 9 p. 716 - 721
反应条件
(S)-selective ω-transaminase from Ochrobactrum anthropi; L-threonine deaminase from Escherichia coli; pyridoxal 5'-phosphate T=37°C; pH=7.5; 7 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Green Chemistry, , vol. 14, # 8 p. 2137 - 2140
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chemical Communications, , # 2 p. 173 - 174
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
参考文献
Kusachi,Shozo; Thompson, Robert D.; Yamada, Nobuyuki; Daly, Daniel T.; Olsson, R. A.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 989 - 996
反应条件
potassium tert-butylate in dimethyl sulfoxide T=120°C; 2 h; Inert atmosphere;
参考文献
SYNTHON BV; DYMACEK, Bohumil
Patent: WO2012/116752 A1, 2012 ;
Location in patent: Page/Page column 13 ;
